Cell Line Development Workflow

This innovative offering is based on uga s well established platform technologies including their proprietary cho host cell lines system optimized expression vectors and.

Cell line development workflow. In cell line development cld you are looking for the rare high producing clones. In the case of monoclonal antibody production the process of developing stable cell lines starts with transfecting host cells with recombinant plasmid dna encoding the. For the greatest genetic diversity you need to screen thousands of cells. Interested in rapid and efficient stable cell pool cell line development for large scale production of your recombinant antibodies and proteins.

Cell line development cld on the beacon optofluidic system enables selection of the best production cell lines with 99 monoclonality assurance in just days. From vector design and host cell selection prior to transfection single cell cloning and colony outgrowth right through to the establishment of the master cell bank solentim technologies provide the evidence for. Single cells proliferate to form colonies that can then be assessed for. The opto cld workflow screens thousands of clones with ease in less than a week.

Based on the suretechnology platform and unique world class expertise selexis sure cell line development services significantly reduce the time effort and costs that are associated with the development of high performance mammalian cell lines for therapeutic protein production e g development of monoclonal antibodies bi specific monoclonal antibodies growth factors and enzymes. Typical cell line workflow. The new opto cld 2 0 workflow extends these capabilities to allow 1 enrichment of rare cell populations 2 on chip titer measurements for traditional and non traditional antibody molecules and 3 efficient recovery. Cell line development campaigns are typically performed over the course of several weeks to months at a time.

We accelerate cell line workflow timelines from upstream development through scale up to production of new biological therapies. The biomek software suite ensures data integrity to provide peace of mind and schedules activities to streamline each automated workflow. Cell line development workflow in order to generate high yields of recombinant protein products stable cell lines such as cho or hek 293 are typical vehicles of choice.